High Performance Liquid Chromatography:Article Title: Benzimidazol-2-amines as mIDH1 inhibitors
Article Snippet: .. The enantiomers of the racemic material of example 2-115 were separated by chiral preparative HPLC (System: 2× Labomatic Pump HD-3000, Labomatic AS-3000, Knauer DAD 2600, Labomatic Labcol Vario 4000 Plus; Column: Chiralpak IF 5 μm 250×30 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 50 mL/min; Temperature: rt; Solution: 520 mg/5 mL DCM/2-propanol; Injection: 4×1.3 mL; Detection: UV 254 nm) and analytically characterized by chiral HPLC (System: Agilent 1260; Column: Chiralpak IF 5 μm 150×4.6 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 1.0 mL/min; Temperature: 25° C.; Solution: 1.0 mg/mL EtOH/MeOH 2:1; Injection: 5.0 μl; Detection: DAD 254 nm) and specific optical rotation: ..
Article Title: Benzimidazol-2-amines as mIDH1 inhibitors
Article Snippet: .. The enantiomers of the racemic material of example 2-166 were separated by chiral preparative HPLC (System: 2× Labomatic Pump HD-3000, Labomatic AS-3000, Knauer DAD 2600, Labomatic Labcol Vario 4000 Plus; Column: Chiralpak ID 5 μm 250×30 mm Nr.: 018 BF; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 50 mL/min; Temperature: rt; Solution: 1400 mg/9.5 mL DCM/MeOH; Injection: 7×1.5 mL; Detection: UV 254 nm) and analytically characterized by chiral HPLC (System: Agilent 1260; Column: Chiralpak ID 5 μm 150×4.6 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 1.0 mL/min; Temperature: 25° C.; Solution: 1.0 mg/mL EtOH/MeOH 2:1; Injection: 5.0 μl; Detection: DAD 254 nm) and specific optical rotation: ..
Solvent:Article Title: Benzimidazol-2-amines as mIDH1 inhibitors
Article Snippet: .. The enantiomers of the racemic material of example 2-115 were separated by chiral preparative HPLC (System: 2× Labomatic Pump HD-3000, Labomatic AS-3000, Knauer DAD 2600, Labomatic Labcol Vario 4000 Plus; Column: Chiralpak IF 5 μm 250×30 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 50 mL/min; Temperature: rt; Solution: 520 mg/5 mL DCM/2-propanol; Injection: 4×1.3 mL; Detection: UV 254 nm) and analytically characterized by chiral HPLC (System: Agilent 1260; Column: Chiralpak IF 5 μm 150×4.6 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 1.0 mL/min; Temperature: 25° C.; Solution: 1.0 mg/mL EtOH/MeOH 2:1; Injection: 5.0 μl; Detection: DAD 254 nm) and specific optical rotation: ..
Article Title: Benzimidazol-2-amines as mIDH1 inhibitors
Article Snippet: .. The enantiomers of the racemic material of example 2-166 were separated by chiral preparative HPLC (System: 2× Labomatic Pump HD-3000, Labomatic AS-3000, Knauer DAD 2600, Labomatic Labcol Vario 4000 Plus; Column: Chiralpak ID 5 μm 250×30 mm Nr.: 018 BF; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 50 mL/min; Temperature: rt; Solution: 1400 mg/9.5 mL DCM/MeOH; Injection: 7×1.5 mL; Detection: UV 254 nm) and analytically characterized by chiral HPLC (System: Agilent 1260; Column: Chiralpak ID 5 μm 150×4.6 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 1.0 mL/min; Temperature: 25° C.; Solution: 1.0 mg/mL EtOH/MeOH 2:1; Injection: 5.0 μl; Detection: DAD 254 nm) and specific optical rotation: ..
Injection:Article Title: Benzimidazol-2-amines as mIDH1 inhibitors
Article Snippet: .. The enantiomers of the racemic material of example 2-115 were separated by chiral preparative HPLC (System: 2× Labomatic Pump HD-3000, Labomatic AS-3000, Knauer DAD 2600, Labomatic Labcol Vario 4000 Plus; Column: Chiralpak IF 5 μm 250×30 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 50 mL/min; Temperature: rt; Solution: 520 mg/5 mL DCM/2-propanol; Injection: 4×1.3 mL; Detection: UV 254 nm) and analytically characterized by chiral HPLC (System: Agilent 1260; Column: Chiralpak IF 5 μm 150×4.6 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 1.0 mL/min; Temperature: 25° C.; Solution: 1.0 mg/mL EtOH/MeOH 2:1; Injection: 5.0 μl; Detection: DAD 254 nm) and specific optical rotation: ..
Article Title: Benzimidazol-2-amines as mIDH1 inhibitors
Article Snippet: .. The enantiomers of the racemic material of example 2-166 were separated by chiral preparative HPLC (System: 2× Labomatic Pump HD-3000, Labomatic AS-3000, Knauer DAD 2600, Labomatic Labcol Vario 4000 Plus; Column: Chiralpak ID 5 μm 250×30 mm Nr.: 018 BF; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 50 mL/min; Temperature: rt; Solution: 1400 mg/9.5 mL DCM/MeOH; Injection: 7×1.5 mL; Detection: UV 254 nm) and analytically characterized by chiral HPLC (System: Agilent 1260; Column: Chiralpak ID 5 μm 150×4.6 mm; Solvent: hexane/2-propanol/diethylamine 70:30:0.1 (v/v/v); Flow: 1.0 mL/min; Temperature: 25° C.; Solution: 1.0 mg/mL EtOH/MeOH 2:1; Injection: 5.0 μl; Detection: DAD 254 nm) and specific optical rotation: ..
|
